Comparison and Clinical Applications of the Frailty Phenotype and Frailty...
The previous chapter focused on the conceptualization and operationalization of the deficit accumulation and phenotypic approaches to the description of frailty. The purpose of this chapter is to...
View ArticleOperationalizing Frailty Using the Frailty Phenotype and Deficit Accumulation...
In both demographic and clinical studies, frailty is understood as a multidimensional state of increased vulnerability compared with the status of others of the same age. Of the many theoretical...
View ArticleFrailty and the Microbiome
From the moment of birth, the human body plays host to a rich diversity of microbes. Body sites such as the skin, the gut and the mouth support communities of microorganisms (collectively known as the...
View ArticleSex Differences in Frailty
Although women live longer lives than men, they tend to have poorer health status. Here, we review the biological and socio-behavioral factors that may contribute to this sex-frailty paradox. The...
View ArticleFrailty, Inflammation and Immunosenescence
Frailty is a still-evolving concept of a complex phenomenon. There are several algorithms and strategies for assessing frailty syndrome, but currently, no universally accepted definition or measurement...
View ArticleAssessment of Frailty in Animal Models
Animal models have contributed greatly to our understanding of the biology of aging and have been used to test new potential interventions to enhance survival. However, whether these interventions can...
View ArticleFrailty: Scaling from Cellular Deficit Accumulation?
Cells age in association with deficit accumulation via mechanisms that are far from fully defined. Even so, how deficits might scale up from the subcellular level to give rise to clinically evident...
View ArticleSubject Index
Theou O, Rockwood K (eds): Frailty in Aging. Biological, Clinical and Social Implications. Interdiscipl Top Gerontol Geriatr. Basel, Karger, 2015, vol 41, pp 197-200
View ArticleAuthor Index
Theou O, Rockwood K (eds): Frailty in Aging. Biological, Clinical and Social Implications. Interdiscipl Top Gerontol Geriatr. Basel, Karger, 2015, vol 41, pp 196
View ArticlePreliminaries
Theou O, Rockwood K (eds): Frailty in Aging. Biological, Clinical and Social Implications. Interdiscipl Top Gerontol Geriatr. Basel, Karger, 2015, vol 41, pp I-X
View ArticleApplication of Geriatric Principles and Care Models in HIV and Aging
People aging with HIV present a unique challenge for providers. HIV-infected patients experience accentuated aging and multimorbidity, but are typically disconnected from geriatric care, which is...
View ArticleDisability among Persons Aging with HIV/AIDS
Persons surviving to older ages with HIV/AIDS often face an accelerated aging accompanied by increased comorbidity and decline in health and function. In this chapter, we review the process of...
View ArticleBehavioral Health
In this chapter, we will describe the state of the literature on behavioral health, which includes mental health and substance use problems, and the available treatment interventions to ameliorate...
View ArticlePolypharmacy, Using New Treatments to Customize Care for Aging Patients and...
Nearly 50% of HIV patients in the US are now over 50, and the problem of comorbidities associated with the aging process is becoming increasingly complicated. In this chapter, we will review the...
View ArticleMultimorbidity and Burden of Disease
With effective antiretroviral therapy, HIV has become a chronic disease, and life expectancy among HIV-infected persons is approaching that of HIV-uninfected persons. Despite this success,...
View ArticleBiomarkers and Clinical Indices of Aging with HIV
HIV infection may potentiate specific biomarkers that influence the development of premature clinical indices commonly associated with aging. Therefore, predicting mortality outcomes in people living...
View ArticleCellular Senescence, Immunosenescence and HIV
Aging is a complex biological process that leads to several physiological changes. Among these changes, the most striking are those involving the innate and adaptive parts of the immune system....
View ArticleAre HIV-Infected Older Adults Aging Differently?
With increasing success in treating HIV, infected persons are living longer, and a new challenge has emerged - the need to understand how HIV-infected adults are aging. What are the similarities with...
View ArticlePreliminaries
Brennan-Ing M, DeMarco RF (eds): HIV and Aging. Interdiscipl Top Gerontol Geriatr. Basel, Karger, 2017, vol 42, pp I-VII
View ArticleLocal and Global HIV Aging Demographics and Research
This introduction serves to foreground current patterns associated with HIV and aging, globally. We highlight key trends by World Health Organization sub-region, and identify gaps in existing...
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